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Formula
C15H11ClFN3O2
MW
319.72
Purity
>97%
Solubility (DMSO Mg/MI)
40
Bio Chemical Notes
A major metabolite of gefitinib, which inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase. Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited, and malignant cells are inhibited. Ref: Science. 2004; 305 (5687), 1163-1167.