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Formula
C19H28ClNO6
MW
401.89
Purity
>97%
Solubility (DMSO Mg/MI)
70
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
N/A
Mode Of Action
modulator
Drug Status
Discontinued in Phase 2
Target Name
NADPH oxidase (NOX)
Research Area
OTHER
Research Area Sub Group
Antiinflammatory
Pharmacology
ENZYMES
Pharmacology Area Sub Group
Oxidase
Bio Chemical Notes
An alkaloid found in Sinomenium acutum, a plant traditionally used in herbal medicine in China and Japan. Sinomenine is a analgesic and anti-inflammatory. This was shown in a study with decreased prostaglandin E2 and leukotriene C4 synthesis of macrophages stimulated by zymosan or calcium ionophore. Ref: Arzneimittelforschung. 1994; 44 (11), 1223-6.